MRL-24

• Catalog number
  2764-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-2-(3-((1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid
• Description
  Cell-permeable. MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ.
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₈H₂₄F₃NO₆
• Molecular Weight
  527.49
• Cell Permeable
  Y
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~ 30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A PPARγ agonist
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• SMILES
  CC1=C(CC2=CC(O[C@H](C(O)=O)C)=CC=C2)C3=CC(OC(F)(F)F)=CC=C3N1C(C4=CC=C(OC)C=C4)=O
• InChi
  InChI=1S/C28H24F3NO6/c1-16-23(14-18-5-4-6-21(13-18)37-17(2)27(34)35)24-15-22(38-28(29,30)31)11-12-25(24)32(16)26(33)19-7-9-20(36-3)10-8-19/h4-13,15,17H,14H2,1-3H3,(H,34,35)
• InChi Key
  OFCWBJAYEIROGZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  MRL-24  
• Gene symbol
  SNORD115-24, SNORD116-24, IGLV3-24, SNORD114-24, CD164, IGHV1-24, ERVW-24, IGKV2-24, IGKV2D-24, DEFB124
• Short name
  MRL-24
• Alternative name
  MRL-24

Gene info

• Identity
  HGNC:33043
• Gene
  SNORD115-24
• Long gene name
  small nucleolar RNA, C/D box 115-24
• Synonyms
  • HBII-52-24
• Locus
  15q11.2
• Discovery year
  2010-10-05
• Entrez gene record
  100036563
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003495
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33090
• Gene
  SNORD116-24
• Long gene name
  small nucleolar RNA, C/D box 116-24
• Synonyms
  • HBII-85-24
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033435
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003338
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5907
• Gene
  IGLV3-24
• Long gene name
  immunoglobulin lambda variable 3-24 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 3-24
  • immunoglobulin lambda variable 3-24 pseudogene
• GenBank acession
  • X71968
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28794
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151230

Gene info

• Identity
  HGNC:33012
• Gene
  SNORD114-24
• Long gene name
  small nucleolar RNA, C/D box 114-24
• Synonyms
  • 14q(II-24)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767604
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003217.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:1632
• Gene
  CD164
• Long gene name
  CD164 molecule
• Synonyms gene name
  • CD164 antigen, sialomucin
  • CD164 molecule, sialomucin
• Synonyms
  • MUC-24
  • MGC-24
  • DFNA66
• Synonyms name
  • deafness, autosomal dominant 66
• GenBank acession
  • AF106518
• Locus
  6q21
• Discovery year
  2000-06-08
• Entrez gene record
  8763
• Pubmed identfication
  • 9680353
  • 9763543
  • 26197441
• RefSeq identity
  • NM_006016
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000015339
• Locus Specific Databases
  • LRG_1419

Gene info

• Identity
  HGNC:5551
• Gene
  IGHV1-24
• Long gene name
  immunoglobulin heavy variable 1-24
• GenBank acession
  • M99642
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28467
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152095

Gene info

• Identity
  HGNC:49312
• Gene
  ERVW-24
• Long gene name
  endogenous retrovirus group W member 24
• Synonyms gene name
  • endogenous retrovirus group W, member 24
• GenBank acession
  • HG421038
• Locus
  12q13.13
• Discovery year
  2013-10-21

Gene info

• Identity
  HGNC:5781
• Gene
  IGKV2-24
• Long gene name
  immunoglobulin kappa variable 2-24
• GenBank acession
  • X12684
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28923
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151655

Gene info

• Identity
  HGNC:5797
• Gene
  IGKV2D-24
• Long gene name
  immunoglobulin kappa variable 2D-24 (non-functional)
• Synonyms gene name
  • immunoglobulin kappa variable 2D-24
• GenBank acession
  • X63401
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28885
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151618

Gene info

• Identity
  HGNC:18104
• Gene
  DEFB124
• Long gene name
  defensin beta 124
• Synonyms gene name
  • defensin, beta 124
• Synonyms
  • DEFB-24
• Synonyms name
  • defensin, beta 24
• GenBank acession
  • DQ119827
• Locus
  20q11.21
• Discovery year
  2002-05-09
• Entrez gene record
  245937
• Pubmed identfication
  • 11854508
  • 16033865
• RefSeq identity
  • NM_001037500
• Classification
  • Defensins, beta
• VEGA ID
  OTTHUMG00000159287

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