Prekallikrein, Human Plasma
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Catalog number
7685-100
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Price
Please ask
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Size
100 ug
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Synonyms
Fletcher factor, Kininogenin.
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Alternative_names
Fletcher factor, Kininogenin.
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Description
Activates plasminogen in fibrinolysis and cleaves kininogen in the bradykinin system of vasodilation.
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Recombinant
No
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Source
Human Plasma
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Biological activity
Lot dependent
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Results
Lot dependent
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Molecular Weight
86 kDa
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Storage Temp
-80°C
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Shipping
Dry Ice
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Shelf Life
12 months
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Appearance
Liquid
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Physical form description
In 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3.
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Background Information
Prekallikrein is the glycosylated single chain zymogen precursor of the plasma serine protease kallikrein. Plasma prekallikrein circulates with kininogen and is activated by Factor XIIa in the intrinsic coagulation pathway. Kallikrein activates plasminogen in fibrinolysis and cleaves kininogen in the bradykinin system of vasodilation. Prekallikrein deficiency is rare and causes increased activated partial thromboplastin time. Elevated plasma prekallikrein is associated with diabetes and cardiovascular disease.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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