PD0332991
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Catalog number2843-25
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PricePlease ask
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Size25 mg
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Alternative_name6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, PD0332991, Palbociclib
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DescriptionPD0332991 is a highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 34 additional protein kinases (IC₅₀ values are > 10 μM).
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CAS Number571190-30-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₂₉N₇O₂
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Molecular Weight447.53
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA potent CDK inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID5330286
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SMILESCC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C
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InChiInChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
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InChi KeyAHJRHEGDXFFMBM-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short namePD0332991
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Alternative namePD0332991
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