Human CellExp™ CSF1R/CD115, mouse recombinant, Fc Tag

• Catalog number
  P1079-10
• Price
  Please ask
• Size
  10 µg

• Synonyms
  CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
• Alternative_names
  CD-115, CD-115 protein, mouse CD-115, recombinant CD-115, mouse recombinant CD-115, mouse CD-115 protein, recombinant CD-115 protein, mouse recombinant CD-115 protein, mouse-r- CD-115, mouse-r- CD-115 protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CD 115, CD 115 protein, mouse CD 115, recombinant CD 115, mouse recombinant CD 115, mouse CD 115 protein, recombinant CD 115 protein, mouse recombinant CD 115 protein, mouse-r- CD 115, mouse-r- CD 115 protein, CD-115, CD-115 protein, mouse CD-115, recombinant CD-115, mouse recombinant CD-115, mouse CD-115 protein, recombinant CD-115 protein, mouse recombinant CD-115 protein, mouse-r- CD-115, mouse-r- CD-115 protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR, September-RP-16
• Description
  Plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells.
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  >95%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1 EU/ug
• Molecular Weight
  81.8 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
• Background Information
  Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   CSF1R/CD115   Tag  
• Gene symbol
  CSF1R
• Short name
  CellExp™ CSF1R/CD115, mouse recombinant, Fc Tag
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  Fc Tag
• Species
  Humans, Mouses
• Alternative name
  H. sapiens CellExp™ colony stimulating factor 1 receptor/CD115, mouse Rec., fragment c detection labelled
• Alternative technique
  rec, murine
• Alternative to gene target
  colony stimulating factor 1 receptor, C-FMS and CD115 and CSF-1R and CSFR and FIM2 and FMS and HDLS and M-CSF-R, CSF1R and IDBG-53268 and ENSG00000182578 and 1436, transferase activity, Cell surfaces, Csf1r and IDBG-150998 and ENSMUSG00000024621 and 12978, CSF1R and IDBG-646265 and ENSBTAG00000012771 and 509418

Gene info

• Identity
  HGNC:2433
• Gene
  CSF1R
• Long gene name
  colony stimulating factor 1 receptor
• Synonyms gene
  • FMS
• Synonyms gene name
  • McDonough feline sarcoma viral (v-fms) oncogene homolog
• Synonyms
  • C-FMS
  • CSFR
  • CD115
• GenBank acession
  • U63963
• Locus
  5q32
• Discovery year
  2001-06-22
• Entrez gene record
  1436
• Pubmed identfication
  • 1611909
• RefSeq identity
  • NM_005211
• Classification
  • Immunoglobulin like domain containing
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000130050

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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