Apoptosis activator 2

• Catalog number
  2784-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
• Description
  Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
• CAS Number
  79183-19-0
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₅H₉Cl₂NO₂
• Molecular Weight
  306.14
• Cell Permeable
  Y
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An apoptosis activator
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD00141556
• PubChem CID
  1901244
• PubChem CID Link
• SMILES
  C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
• InChi
  InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
• InChi Key
  KGRJPLRFGLMQMV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  This 1 is suited for programmed cell-death studies.

• Gene target
  activator  
• Gene symbol
  CADPS2, STAT2, PSME2P1
• Short name
  Apoptosis activator 2
• Technique
  apoptosis, apoptosis pathway
• Alternative name
  programmed cellular destruction activator 2
• Alternative technique
  celldeath

Gene info

• Identity
  HGNC:16018
• Gene
  CADPS2
• Long gene name
  calcium dependent secretion activator 2
• Synonyms gene name
  • Ca++-dependent activator protein for secretion 2
  • Ca2+ dependent secretion activator 2
• Synonyms
  • CAPS2
• Locus
  7q31.32
• Discovery year
  2001-07-12
• Entrez gene record
  93664
• RefSeq identity
  • NM_017954
• Classification
  • C2 domain containing
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000157093

Gene info

• Identity
  HGNC:11363
• Gene
  STAT2
• Long gene name
  signal transducer and activator of transcription 2
• Synonyms gene name
  • signal transducer and activator of transcription 2, 113kD
  • signal transducer and activator of transcription 2, 113kDa
• Synonyms
  • STAT113
• GenBank acession
  • BC051284
• Locus
  12q13.3
• Discovery year
  1995-11-08
• Entrez gene record
  6773
• Pubmed identfication
  • 7885841
• RefSeq identity
  • NM_005419
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000170760
• Locus Specific Databases
  • LRG_1329

Gene info

• Identity
  HGNC:20632
• Gene
  PSME2P1
• Long gene name
  proteasome activator subunit 2 pseudogene 1
• Synonyms gene
  • PSME2P
• Synonyms gene name
  • proteasome (prosome, macropain) activator subunit 2 pseudogene
• GenBank acession
  • AC116347
• Locus
  5q15
• Discovery year
  2003-03-10
• Entrez gene record
  257093
• RefSeq identity
  • NG_002626

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