Lithium Assay Kit (Colorimetric)

• Catalog number
  K545-100
• Price
  Please ask
• Size
  100 assays

• Description
  The first and most sensitive kit in the market that measures exogenous levels of Lithium
• Summary
  • Detection method- Absorbance (540 nm/630 ratio) • Application- The kit can detect Lithium concentration as low as 100 µM in human serum
• Detection Method
  Absorbance (540 nm/630 ratio)
• Species Reactivity
  Eukaryotes
• Applications
  The kit can detect Lithium concentration as low as 100 µM in human serum
• Sample Type
  Biological fluids: serum/plasma, etc.)
• Features Benefits
  • Simple, one-step colorimetric assay • Endogenous mono-, di-, and trivalent ions do not interfere with the assay • The kit can detect Lithium concentration as low as 100 µM in a variety of samples
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Lithium, the lightest alkali metal element, is a ductile, reactive metal that occurs in nature as the Li+ cation and is found in various mineral compounds. Physiologically, lithium is present only in trace levels and is not considered to be an essential dietary nutrient. However, lithium is routinely used in medicine as a psychoactive drug. Lithium acts as a mood stabilizer and is considered to be the gold standard first-line treatment for bipolar depression and acute mania. Patients treated with lithium are less likely to require hospitalization or complete suicide than patients treated with other mood stabilizers or antipsychotics. Chemically, lithium is the simplest possible drug—as an element, it is not metabolized by the body and has zero-order renal elimination kinetics. Lithium has a narrow therapeutic/toxic ratio and requires blood level monitoring, both to ensure efficacy and decrease the risk of toxic side-effects. The target serum concentration for lithium maintenance therapy ranges from 0.6-1.2 mM. At serum levels ≥1.5 mM there is a sharp increase in severe adverse effects. Overt, potentially fatal side effects (such as seizures, ataxia and loss of consciousness) are observed at serum levels >2.5 mM. BioVision’s Lithium Assay Kit allows for quantification of lithium levels in biological fluids such as serum and plasma. The assay uses a lithium-selective bichromatic probe that undergoes an absorbance change at two distinct wavelengths upon binding to Li+ (λ1 = 540 nm, λ2 = 630 nm). The ratio of the two optical measurements is used to accurately calculate sample Li+ concentration. The kit also includes a sodium masking reagent to prevent the possibility of interference by supra-physiological levels of serum Na+ (hypernatremia). The assay is quick, is high-throughput adaptable and has a linear range from 0.5 – 10 nmole lithium per well (corresponding to 0.1 – 2 mM serum lithium)
• Data Sheet Link
• Test
  Biovision supplies other types of Assays as 1.
• Properties
  Colorimetric assays or detection use UV absorption or enzymatic color reaction.

• Gene target
  Lithium   Kit  
• Short name
  Lithium Assay Kit (Colorimetric)
• Technique
  colorimetric, Assay, assays, colorimetry
• Host
  Assay
• Alternative name
  Lithium test reagent (colorimetry)
• Alternative technique
  assays, arrays, kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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