LY-2835219
-
Catalog numberB1039-10
-
PricePlease ask
-
Size10 mg
-
-
Alternative_nameN-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine; Abemaciclib
-
DescriptionLY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC₅₀ of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates dose-dependent growth inhibition in ER+ breast cancer models.
-
CAS Number1231930-82-7
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₇H₃₂F₂N₈.CH₄O₃S
-
Molecular Weight602.7
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (>50 mg/ml) or H₂O (>60 mg/ml)
-
HandlingProtect from air and moisture
-
Tag LineA potent and selective inhibitor of CDK4 and CDK6
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
PubChem CID71576678
-
SMILESCCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
-
InChiInChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
-
InChi KeyNCJPFQPEVDHJAZ-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Gene target
-
Gene symbolARHGDIB
-
Short nameLY-2835219
-
Alternative nameLY-2835219
-
Gene info
-
Identity
-
Gene
-
Long gene nameRho GDP dissociation inhibitor beta
-
Synonyms gene
-
Synonyms gene name
- Rho GDP dissociation inhibitor (GDI) beta
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1994-08-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Receptor ligands
- Minor histocompatibility antigens
-
VEGA ID