A-366
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Catalog number2859-5
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PricePlease ask
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Size5 mg
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Alternative_name5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
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DescriptionA-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM.
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CAS Number1527503-11-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₉H₂₇N₃O₂
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Molecular Weight329.44
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>25 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent and selective G9a/GLP histone lysine methyltransferase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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SMILESNC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3
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InChiInChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
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InChi KeyBKCDJTRMYWSXMC-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolHLA-A, IGHV5-10-1, CIDEA, RPA1, CDC37P1, OR1Q1, LINC01139, FABP4, GTF2E1
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Short nameA-366
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Alternative nameA-366
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Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, A
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 5-10-1
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Synonyms gene
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Synonyms gene name
- immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
- immunoglobulin heavy variable 5-A (provisional)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell death inducing DFFA like effector a
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Synonyms gene name
- cell death-inducing DFFA-like effector a
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namereplication protein A1
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Synonyms gene name
- replication protein A1 (70kD)
- replication protein A1, 70kDa
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-12-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Nucleotide excision repair
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell division cycle 37 pseudogene 1
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Synonyms gene name
- cell division cycle 37 homolog (S. cerevisiae) pseudogene 1
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Synonyms
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Locus
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Discovery year2009-01-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 1 subfamily Q member 1
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Synonyms gene
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Synonyms gene name
- olfactory receptor, family 1, subfamily Q, member 1
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Synonyms
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Locus
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Discovery year1999-12-09
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Entrez gene record
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Classification
- Olfactory receptors, family 1
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelong intergenic non-protein coding RNA 1139
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Synonyms
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Synonyms name
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Locus
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Discovery year2013-12-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long intergenic non-protein coding RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid binding protein 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fatty acid binding protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegeneral transcription factor IIE subunit 1
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Synonyms gene name
- general transcription factor IIE, polypeptide 1 (alpha subunit, 56kD)
- general transcription factor IIE, polypeptide 1, alpha 56kDa
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-08-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- General transcription factor IIE complex subunits
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VEGA ID