Dinaciclib

• Catalog number
  9537-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol; SCH-727965
• Description
  Dinaciclib is a potent and selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 with IC₅₀ values of 3, 1, 1 and 4 nM respectively. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC₅₀ value of 4 nM.
• CAS Number
  779353-01-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₈N₆O₂
• Molecular Weight
  396.49
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent CDK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  46926350
• PubChem CID Link
• SMILES
  CC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO
• InChi
  InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1
• InChi Key
  PIMQWRZWLQKKBJ-SFHVURJKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Dinaciclib  
• Short name
  Dinaciclib
• Alternative name
  Dinaciclib

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