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Gene info
IPR1 Antibody: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
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Gene names
IPR1 Antibody: IPR1, VODI, IFI41, IFI75, Sp110 nuclear body protein, Speckled 110 kDa
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Antibodie s label
unlabelled serum
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Purity
IPR1 Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Antigen
IPR1 antibody was made against a 16 amino acid synthetic peptide near the amino terminus of the human IPR1.
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Immuno application
ELISA, Western Blot
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Antibody advice
Ipr1 antibody can be used for detection of Ipr1 by Western blot at 1 - 2 ug/mL.
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Suspention pH azide
IPR1 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
IPR1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human, Mouse, Rat
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Omim nr
190343008
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Ncbi nr
NP_004501
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
3431
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GENE symbol
SP110
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Antigene name
SP110 nuclear body protein
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Source
Homo sapiens
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Protein nr
Q9HB58
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
