27-Hydroxycholesterol

• Catalog number
  B2988-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (25R)-26-hydroxy Cholesterol; (3β,25R)-Cholest-5-ene-3,26-diol; 25(R)-27-hydroxy Cholesterol
• Description
  27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis. The levels of 27-hydroxycholesterol are elevated in patients with Alzheimer's disease and mild cognitive impairment.
• CAS Number
  20380-11-4
• Structure Available
  True
• Salt Form
  False
• Molecular Formula
  C₂₇H₄₆O₂
• Molecular Weight
  402.65
• Cell Permeable
  True
• Purity
  0.98
• Solubilities
  ~20 mg/ml in Ethanol, ~2 mg/ml in DMF, ~0.1 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A hydroxylation product of cholesterol and LXRα and LXRβ activator
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD00272990
• PubChem CID
  123976
• PubChem CID Link
• SMILES
  CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO
• InChi
  InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChi Key
  FYHRJWMENCALJY-YSQMORBQSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  27-Hydroxycholesterol  
• Gene symbol
  SNORD115-27, IGKV1D-27, ERVK-27, ERVW-27, RNVU1-27, IGHV7-27, SNORD116-27, SNORD114-27, IGLV3-27, IGHD7-27
• Short name
  27-Hydroxycholesterol
• Alternative name
  27-Hydroxycholesterol

Gene info

• Identity
  HGNC:33046
• Gene
  SNORD115-27
• Long gene name
  small nucleolar RNA, C/D box 115-27
• Synonyms
  • HBII-52-27
• Locus
  15q11.2
• Discovery year
  2011-08-22
• Entrez gene record
  100036564
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003496
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5751
• Gene
  IGKV1D-27
• Long gene name
  immunoglobulin kappa variable 1D-27 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 1D-27
• GenBank acession
  • Z00004
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28898
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151607

Gene info

• Identity
  HGNC:44980
• Gene
  ERVK-27
• Long gene name
  endogenous retrovirus group K member 27
• Synonyms gene name
  • endogenous retrovirus group K, member 27
• GenBank acession
  • JZ164909
• Locus
  11q12.3
• Discovery year
  2014-01-03
• Pubmed identfication
  • 23338945

Gene info

• Identity
  HGNC:49315
• Gene
  ERVW-27
• Long gene name
  endogenous retrovirus group W member 27
• Synonyms gene name
  • endogenous retrovirus group W, member 27
• GenBank acession
  • HG421064
• Locus
  14q32.12
• Discovery year
  2013-10-21

Gene info

• Identity
  HGNC:54431
• Gene
  RNVU1-27
• Long gene name
  RNA, variant U1 small nuclear 27
• Locus
  1q21.2
• Discovery year
  2019-07-26
• Classification
  • Variant U1 small nuclear RNAs

Gene info

• Identity
  HGNC:5663
• Gene
  IGHV7-27
• Long gene name
  immunoglobulin heavy variable 7-27 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 7-27
  • immunoglobulin heavy variable 7-27 pseudogene
• GenBank acession
  • M99643
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28383
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152070

Gene info

• Identity
  HGNC:33093
• Gene
  SNORD116-27
• Long gene name
  small nucleolar RNA, C/D box 116-27
• Synonyms
  • HBII-85-27
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033439
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003341
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33015
• Gene
  SNORD114-27
• Long gene name
  small nucleolar RNA, C/D box 114-27
• Synonyms
  • 14q(II-27)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767608
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003220.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5910
• Gene
  IGLV3-27
• Long gene name
  immunoglobulin lambda variable 3-27
• GenBank acession
  • D86994
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28791
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151171

Gene info

• Identity
  HGNC:5518
• Gene
  IGHD7-27
• Long gene name
  immunoglobulin heavy diversity 7-27
• Synonyms
  • IGHD727
  • DHQ52
• GenBank acession
  • J00256
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28484
• Pubmed identfication
  • 6795593
  • 6101209
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152435

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