Phlorizin
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Catalog number2416-500
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PricePlease ask
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Size500 mg
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Alternative_name1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; NSC 2833; Florizidin
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DescriptionPhlorizin is a competitive inhibitor of SGLT1 (sodium glucose co-transporter 1) and SGLT2 (sodium glucose co-transporter 2); this reduces renal glucose transport, lowering the amount of glucose in the blood. It competitively inhibits the initial rate of α-methyl-D-glucopyranoside (α-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC₅₀ values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.
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CAS Number60-81-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₁H₂₄O₁₀
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Molecular Weight436.41
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Cell PermeableNo
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Purity≥98%
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SolubilitiesDMSO (~30 mg/ml) or EtOH (~ 5 mg/ml)
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HandlingProtect from light and air
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Tag LineA competitive inhibitor of SGLT1 and SGLT2
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00149438
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PubChem CID6072
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SMILESC1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O
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InChiInChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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InChi KeyIOUVKUPGCMBWBT-QNDFHXLGSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolLCTL
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Short namePhlorizin
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Alternative namePhlorizin
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Gene info
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Identity
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Gene
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Long gene namelactase like
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-07-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Glycoside hydrolase family 1
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VEGA ID