GJ-103 Sodium salt

• Catalog number
  B1842-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate sodium
• Description
  GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. It induces ATM kinase activity in A-T cells carrying different homozygous nonsense mutations; this analog is also active in A-T cells containing TAG or TAA stop codons.
• CAS Number
  1459687-96-7
• Structure Available
  Yes
• Molecular Formula
  C₁₆H₁₃N₄NaO₃S
• Molecular Weight
  364.35
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  H₂O
• Handling
  Protect from air and moisture
• Tag Line
  An active, water-soluble analog of the read-through compound GJ072.
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  71748052
• PubChem CID Link
• SMILES
  COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)[O-])C3=CC=CC=N3.[Na+]
• InChi
  InChI=1S/C16H14N4O3S.Na/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22;/h2-9H,10H2,1H3,(H,21,22);/q;+1/p-1
• InChi Key
  PTFQBXAUOWUATD-UHFFFAOYSA-M
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GJ-103   Sodium   salt  
• Gene symbol
  IFFO1, MIR103B1, MIR103A1, MIR103A2, MIR103B2
• Short name
  GJ-103 Sodium salt
• Alternative name
  GJ-103 Sodium salt

Gene info

• Identity
  HGNC:24970
• Gene
  IFFO1
• Long gene name
  intermediate filament family orphan 1
• Synonyms gene
  • IFFO
• Synonyms gene name
  • intermediate filament family orphan
• Synonyms
  • HOM-TES-103
• GenBank acession
  • AF124432
• Locus
  12p13.31
• Discovery year
  2008-02-26
• Entrez gene record
  25900
• Pubmed identfication
  • 8771189
  • 3052284
  • 31548606
• RefSeq identity
  • NM_080730
• Classification
  • Intermediate filament family orphans
• VEGA ID
  OTTHUMG00000141264

Gene info

• Identity
  HGNC:35384
• Gene
  MIR103B1
• Long gene name
  microRNA 103b-1
• Synonyms gene
  • MIRN103-1AS
  • MIR103-1AS
• Synonyms gene name
  • microRNA 103-1-as
• Synonyms
  • hsa-mir-103-1-as
  • hsa-mir-103b-1
• Locus
  5q34
• Discovery year
  2008-11-03
• Entrez gene record
  100302238
• Pubmed identfication
  • 18524951
• RefSeq identity
  • NR_031721
• Classification
  • MicroRNA MIR103/107 family

Gene info

• Identity
  HGNC:31490
• Gene
  MIR103A1
• Long gene name
  microRNA 103a-1
• Synonyms gene
  • MIRN103-1
  • MIR103-1
• Synonyms gene name
  • microRNA 103-1
• Synonyms
  • hsa-mir-103-1
  • hsa-mir-103a-1
• Locus
  5q34
• Discovery year
  2004-04-23
• Entrez gene record
  406895
• RefSeq identity
  • NR_029520
• Classification
  • MicroRNA MIR103/107 family

Gene info

• Identity
  HGNC:31491
• Gene
  MIR103A2
• Long gene name
  microRNA 103a-2
• Synonyms gene
  • MIRN103-2
  • MIR103-2
• Synonyms gene name
  • microRNA 103-2
• Synonyms
  • hsa-mir-103-2
  • hsa-mir-103a-2
• Locus
  20p13
• Discovery year
  2004-04-23
• Entrez gene record
  406896
• RefSeq identity
  • NR_029519
• Classification
  • MicroRNA MIR103/107 family

Gene info

• Identity
  HGNC:35385
• Gene
  MIR103B2
• Long gene name
  microRNA 103b-2
• Synonyms gene
  • MIRN103-2AS
  • MIR103-2AS
• Synonyms gene name
  • microRNA 103-2-as
• Synonyms
  • hsa-mir-103-2-as
  • hsa-mir-103b-2
• Locus
  20p13
• Discovery year
  2008-11-03
• Entrez gene record
  100302282
• RefSeq identity
  • NR_031722
• Classification
  • MicroRNA MIR103/107 family

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