GW-4064

• Catalog number
  B2278-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
• Description
  GW-4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC₅₀ = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.
• CAS Number
  278779-30-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₈H₂₂Cl₃NO₄
• Molecular Weight
  542.84
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective, non-steroidal farnesoid X receptor (FXR) agonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD09971006
• PubChem CID
  9893571
• PubChem CID Link
• SMILES
  CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl
• InChi
  InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)
• InChi Key
  BYTNEISLBIENSA-MDZDMXLPSA-N
• Data Sheet Link
• MSDS Available
  YES

• Gene target
  GW-4064  
• Short name
  GW-4064
• Alternative name
  GW-4064

Similar products