STF-62247

• Catalog number
  B2210-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
• Description
  STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC₅₀ = 625 nM). STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL.
• CAS Number
  315702-99-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₃N₃S
• Molecular Weight
  267.35
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An autophagy inducer and an anticancer agent
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  704473
• PubChem CID Link
• SMILES
  CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• InChi
  InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
• InChi Key
  KATNUHQNJGNLPW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  STF-62247  
• Gene symbol
  PDX1
• Short name
  STF-62247
• Alternative name
  STF-62247

Gene info

• Identity
  HGNC:6107
• Gene
  PDX1
• Long gene name
  pancreatic and duodenal homeobox 1
• Synonyms gene
  • IPF1
• Synonyms gene name
  • insulin promoter factor 1, homeodomain transcription factor
• Synonyms
  • IDX-1
  • STF-1
  • PDX-1
  • MODY4
• Synonyms name
  • somatostatin transcription factor 1
• GenBank acession
  • AF035260
• Locus
  13q12.2
• Discovery year
  1995-01-30
• Entrez gene record
  3651
• Pubmed identfication
  • 7590740
• RefSeq identity
  • NM_000209
• Classification
  • HOXL subclass homeoboxes
• VEGA ID
  OTTHUMG00000016638

Product images

Similar products