Z-VAD-FMK

Alternative_name

Z-VAD-FMK, Caspase-Family Inhibitor (fluoromethylketone)
Description

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
CAS Number

187389-52-2
Structure Available

No
Peptide sequence

Z-Val-Ala-Asp(OMe)-FMK
Salt Form

No
Molecular Formula

C₂₂H₃₀N₃O₇F
Molecular Weight

467.5
Cell Permeable

yes
Purity

Single spot by TLC
Solubilities

DMSO (20 mM)
Handling

Protect from light and moisture
Tag Line

A pan-caspase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

12 months
MDL Number

MFCD01074990
PubChem CID

5737
PubChem CID Link
SMILES

CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi

InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)
InChi Key

MIFGOLAMNLSLGH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042