IWP-3

• Catalog number
  2349-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Inhibitor of Wnt Production-3; 2-​[[3-​(4-​fluorophenyl)-​3,​4,​6,​7-​tetrahydro-​4-​oxothieno[3,​2-​ d]pyrimidin-​2-​yl]thio]-​N-​(6-​methyl-​2-​benzothiazolyl)-​acetamide
• Description
  An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
• CAS Number
  687561-60-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₁₇FN₄O₂S₃
• Molecular Weight
  484.59
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (~2 mg/ml on warming)
• Handling
  Protect from air and light
• Tag Line
  An inhibitor of Wnt production
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD04457889
• SMILES
  O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O
• InChi
  InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
• InChi Key
  XVMHQSDMKWQNBK-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  IWP-3  
• Gene symbol
  MIR1302-3, MIR509-3, MIR7-3, PIRC14, PIRC12, MIR9-3, MIR941-3, PIRC15
• Short name
  IWP-3
• Alternative name
  IWP-3

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37518
• Gene
  PIRC14
• Long gene name
  piwi-interacting RNA cluster 14
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313784
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37516
• Gene
  PIRC12
• Long gene name
  piwi-interacting RNA cluster 12
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313808
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:31646
• Gene
  MIR9-3
• Long gene name
  microRNA 9-3
• Synonyms gene
  • MIRN9-3
• Synonyms
  • hsa-mir-9-3
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407051
• RefSeq identity
  • NR_029692
• Classification
  • MicroRNA MIR9 family

Gene info

• Identity
  HGNC:33686
• Gene
  MIR941-3
• Long gene name
  microRNA 941-3
• Synonyms gene
  • MIRN941-3
• Synonyms
  • hsa-mir-941-3
• Locus
  20q13.33
• Discovery year
  2007-10-24
• Entrez gene record
  100126352
• RefSeq identity
  • NR_030639
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:37519
• Gene
  PIRC15
• Long gene name
  piwi-interacting RNA cluster 15
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313848
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Similar products