TP-0903

Alternative_name

2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
Description

TP-0903 is a potent and selective AXL Inhibitor (IC₅₀ = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD₅₀ values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents.
CAS Number

1341200-45-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₄H₃₀ClN₇O₂S
Molecular Weight

516.06
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>5 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective AXL kinase Inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

56839178
PubChem CID Link
SMILES

CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl
InChi

InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
InChi Key

YUAALFPUEOYPNX-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:6525
Gene

LCN1
Long gene name

lipocalin 1
Synonyms gene name
- lipocalin 1 (protein migrating faster than albumin, tear prealbumin)
- lipocalin 1 (tear prealbumin)
Synonyms
- VEGP
- TP
- PMFA
- MGC71975
- TLC
Synonyms name
Locus

9q34.3
Discovery year

1993-05-03
Entrez gene record

3933
Pubmed identfication
- 8276406
RefSeq identity
- NM_002297
Classification
- Lipocalins
VEGA ID

OTTHUMG00000020908