GSK-583

Alternative_name

6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine
Description

GSK-583 is a highly potent and selective Inhibitor of RIP2 Kinase (IC₅₀ = 5 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.
CAS Number

1346547-00-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₉FN₄O₂S
Molecular Weight

398.46
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>10 mg/ml)
Handling

Protect from air and light
Tag Line

A highly potent and selective Inhibitor of RIP2 Kinase
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

67469084
PubChem CID Link
SMILES

CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
InChi

InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChi Key

XLOGLWKOHPIJLV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes