CO-1686

• Catalog number
  HY-15729
• Price
  Please ask
• Size
  100mg

• Alternative_Names
  Rociletinib;AVL-301;CNX-419
• CAS
  1374640-70-6
• MWt
  555.55
• Formula
  C27H28F3N7O3
• Solubility
  DMSO: ≥ 43 mg/mL
• Clinical_Information
  Phase 3
• Pathway
  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
• Target
  EGFR;EGFR
• Datasheet
• SDS

• Gene target
  CO-1686  
• Gene symbol
  TSPAN8, AQP1, ENTR1, CWC27, UTP14A, NOXA1, HDAC5, TSHZ1, NEMF, USH1C
• Short name
  CO-1686
• Alternative name
  CO-1686

Gene info

• Identity
  HGNC:11855
• Gene
  TSPAN8
• Long gene name
  tetraspanin 8
• Synonyms gene
  • TM4SF3
• Synonyms gene name
  • transmembrane 4 superfamily member 3
• Synonyms
  • CO-029
• GenBank acession
  • M35252
• Locus
  12q21.1
• Discovery year
  1997-10-16
• Entrez gene record
  7103
• Pubmed identfication
  • 2395876
• RefSeq identity
  • NM_004616
• Classification
  • Tetraspanins
• VEGA ID
  OTTHUMG00000169542

Gene info

• Identity
  HGNC:633
• Gene
  AQP1
• Long gene name
  aquaporin 1 (Colton blood group)
• Synonyms gene
  • CO
• Synonyms gene name
  • Colton blood group
  • aquaporin 1 (channel-forming integral protein, 28kDa)
  • aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group)
  • aquaporin 1
• Synonyms
  • CHIP28
• GenBank acession
  • M77829
• Locus
  7p14.3
• Discovery year
  1993-07-09
• Entrez gene record
  358
• Pubmed identfication
  • 1722319
  • 3166547
• RefSeq identity
  • NM_198098
• Classification
  • Blood group antigens
  • Aquaporins
• VEGA ID
  OTTHUMG00000023944
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_808

Gene info

• Identity
  HGNC:10667
• Gene
  ENTR1
• Long gene name
  endosome associated trafficking regulator 1
• Synonyms gene
  • SDCCAG3
• Synonyms gene name
  • serologically defined colon cancer antigen 3
• Synonyms
  • NY-CO-3
• GenBank acession
  • AF039688
• Locus
  9q34.3
• Discovery year
  1999-08-25
• Entrez gene record
  10807
• Pubmed identfication
  • 9610721
• RefSeq identity
  • NM_006643
• VEGA ID
  OTTHUMG00000020928

Gene info

• Identity
  HGNC:10664
• Gene
  CWC27
• Long gene name
  CWC27 spliceosome associated cyclophilin
• Synonyms gene
  • SDCCAG10
• Synonyms gene name
  • serologically defined colon cancer antigen 10
  • CWC27 spliceosome-associated protein homolog (S. cerevisiae)
  • CWC27 spliceosome-associated protein homolog
  • CWC27 spliceosome associated protein homolog
• Synonyms
  • NY-CO-10
  • SDCCAG-10
• GenBank acession
  • AF039692
• Locus
  5q12.3
• Discovery year
  1999-07-23
• Entrez gene record
  10283
• Pubmed identfication
  • 9610721
  • 19941820
  • 28285769
• RefSeq identity
  • NM_005869
• Classification
  • Cyclophilin peptidylprolyl isomerases
  • Spliceosomal C complex
  • NTC associated proteins
  • Spliceosomal Bact complex
  • Spliceosomal P complex
• VEGA ID
  OTTHUMG00000074069

Gene info

• Identity
  HGNC:10665
• Gene
  UTP14A
• Long gene name
  UTP14A small subunit processome component
• Synonyms gene
  • SDCCAG16
• Synonyms gene name
  • serologically defined colon cancer antigen 16
  • UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
• Synonyms
  • NY-CO-16
  • Utp14
• GenBank acession
  • AF039694
• Locus
  Xq26.1
• Discovery year
  1999-08-25
• Entrez gene record
  10813
• Pubmed identfication
  • 9610721
  • 16354793
  • 21078665
• RefSeq identity
  • NM_006649
• Classification
  • SSU processome
• VEGA ID
  OTTHUMG00000022378

Gene info

• Identity
  HGNC:10668
• Gene
  NOXA1
• Long gene name
  NADPH oxidase activator 1
• Synonyms gene
  • SDCCAG31
• Synonyms gene name
  • serologically defined colon cancer antigen 31
• Synonyms
  • NY-CO-31
  • FLJ25475
• GenBank acession
  • AF039697
• Locus
  9q34.3
• Discovery year
  1999-08-25
• Entrez gene record
  10811
• Pubmed identfication
  • 9610721
• VEGA ID
  OTTHUMG00000131781

Gene info

• Identity
  HGNC:14068
• Gene
  HDAC5
• Long gene name
  histone deacetylase 5
• Synonyms
  • KIAA0600
  • NY-CO-9
  • FLJ90614
• GenBank acession
  • AF249731
• Locus
  17q21.31
• Discovery year
  2000-11-28
• Entrez gene record
  10014
• Pubmed identfication
  • 10220385
  • 9610721
• RefSeq identity
  • NM_001015053
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000181806

Gene info

• Identity
  HGNC:10669
• Gene
  TSHZ1
• Long gene name
  teashirt zinc finger homeobox 1
• Synonyms gene
  • SDCCAG33
• Synonyms gene name
  • serologically defined colon cancer antigen 33
  • teashirt zinc finger 1
  • teashirt family zinc finger 1
• Synonyms
  • NY-CO-33
  • TSH1
• GenBank acession
  • AF039698
• Locus
  18q22.3
• Discovery year
  1999-07-23
• Entrez gene record
  10194
• Pubmed identfication
  • 17586487
• RefSeq identity
  • NM_005786
• Classification
  • ZF class homeoboxes and pseudogenes
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000132859

Gene info

• Identity
  HGNC:10663
• Gene
  NEMF
• Long gene name
  nuclear export mediator factor
• Synonyms gene
  • SDCCAG1
• Synonyms gene name
  • serologically defined colon cancer antigen 1
• Synonyms
  • NY-CO-1
  • FLJ10051
• Synonyms name
  • caliban homolog (Drosophila)
• GenBank acession
  • AF039687
• Locus
  14q21.3
• Discovery year
  1999-02-09
• Entrez gene record
  9147
• Pubmed identfication
  • 9610721
  • 10575219
• RefSeq identity
  • NM_004713
• VEGA ID
  OTTHUMG00000170857

Gene info

• Identity
  HGNC:12597
• Gene
  USH1C
• Long gene name
  USH1 protein network component harmonin
• Synonyms gene
  • DFNB18
• Synonyms gene name
  • deafness, autosomal recessive 18
  • Usher syndrome 1C (autosomal recessive, severe)
  • Usher syndrome 1C
• Synonyms
  • PDZ73
  • harmonin
  • NY-CO-37
  • NY-CO-38
  • PDZ-73
  • AIE-75
  • PDZD7C
• Synonyms name
  • harmonin
• GenBank acession
  • AB006955
• Locus
  11p15.1
• Discovery year
  1992-06-08
• Entrez gene record
  10083
• Pubmed identfication
  • 10973247
  • 12107438
• RefSeq identity
  • NM_005709
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000166323
• Locus Specific Databases
  • Mutations of the Harmonin Gene
  • CCHMC-BMI & UC Hearing Loss Mutation Database

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