Heparanase Antibody, ALEXA FLUOR 555

• Catalog number
  bs-10484R-A555
• Price
  Please ask
• Size
  100ul

• Long name
  Heparanase Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
• Also known as
  Anti-Heparanase PAb ALEXA FLUOR 555
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 555
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Heparanase
• Specificity
  This is a highly specific antibody against Heparanase.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Heparanase
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  553nm/568nm
• Synonyms
  Heparanase 50 kDa subunit; heparanase; heparanase1; heparanase-1; heparanase 1; Endo glucoronidase; Endo glucoronidase; Endo-glucoronidase; HPSE_HUMAN; Heparanase1; Heparanase 1; HEP; Hpa 1; HPA; Hpa1; HPR 1; HPR1; HPSE 1; HPSE; HPSE1; HSE 1; HSE1.
• Properties
  For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 555
• French translation
  anticorps

• Gene target
  Heparanase  
• Gene symbol
  HPSE2, HPSE
• Short name
  Anti-Heparanase
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 555
• Alternative name
  Heparanase Polyclonal Antibody, ALEXA FLUOR 555
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:18374
• Gene
  HPSE2
• Long gene name
  heparanase 2 (inactive)
• Synonyms gene
  • UFS
• Synonyms gene name
  • urofacial syndrome
  • heparanase 2
• Synonyms
  • HPA2
  • HPR2
• GenBank acession
  • AF282885
• Locus
  10q24.2
• Discovery year
  2002-09-02
• Entrez gene record
  60495
• Pubmed identfication
  • 11027606
  • 20560210
  • 9199567
  • 20576607
• RefSeq identity
  • NM_021828
• Classification
  • Heparanases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000018880

Gene info

• Identity
  HGNC:5164
• Gene
  HPSE
• Long gene name
  heparanase
• Synonyms
  • HPA
  • HSE1
  • HPSE1
• GenBank acession
  • AF144325
• Locus
  4q21.23
• Discovery year
  1999-09-28
• Entrez gene record
  10855
• Pubmed identfication
  • 10395325
  • 10395326
• RefSeq identity
  • NM_006665
• Classification
  • Heparanases
• VEGA ID
  OTTHUMG00000130425

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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