PQR-309

Alternative_name

5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
Description

PQR-309 is a potent pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PQR-309 inhibits the PI3K kinase isoforms α, β, g and δ, and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR.
CAS Number

1225037-39-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₇H₂₀F₃N₇O₂
Molecular Weight

411.39
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR)
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

58507717
PubChem CID Link
SMILES

C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
InChi

InChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)
InChi Key

ADGGYDAFIHSYFI-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:10609
Gene

CCL1
Long gene name

C-C motif chemokine ligand 1
Synonyms gene
- SCYA1
Synonyms gene name
- small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
- chemokine (C-C motif) ligand 1
Synonyms
- I-309
- TCA3
- P500
- SISe
Synonyms name
- inflammatory cytokine I-309
- T lymphocyte-secreted protein I-309
GenBank acession
- M57506
Locus

17q12
Discovery year

1990-07-05
Entrez gene record

6346
Pubmed identfication
- 2212659
- 10409433
RefSeq identity
- NM_002981
Classification
- Chemokine ligands
VEGA ID

OTTHUMG00000132888