Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.
3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
Is this a salt?
Is it cell-permeable?
≥98% by TLC
DMSO (20 mg/ml)
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
LDN-57444 for activation
LDN-57444 to measure cellular activation