KN-93

Alternative_name

N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide
Description

Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes.
CAS Number

139298-40-1
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₆H₂₉ClN₂O₄S
Molecular Weight

501.04
Cell Permeable

Yes
Purity

≥98%
Solubilities

DMSO (>40 mg/ml)
Handling

Protect from air and light
Tag Line

A Ca²⁺/calmodulin-dependent kinase type II inhibitor
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

24 months
MDL Number

MFCD03788201
PubChem CID

5312122
PubChem CID Link
SMILES

CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
InChi

InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChi Key

LLLQTDSSHZREGW-AATRIKPKSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:2334
Gene

CR1
Long gene name

complement C3b/C4b receptor 1 (Knops blood group)
Synonyms gene name
- complement component (3b/4b) receptor 1, including Knops blood group system
- complement component (3b/4b) receptor 1 (Knops blood group)
- complement component 3b/4b receptor 1 (Knops blood group)
Synonyms
- CD35
- KN
GenBank acession
- Y00816
Locus

1q32.2
Discovery year

2001-06-22
Entrez gene record

1378
Pubmed identfication
- 1708809
RefSeq identity
- NM_000573
Classification
- Blood group antigens
- Complement system regulators and receptors
- CD molecules
- Sushi domain containing
VEGA ID

OTTHUMG00000036311
Locus Specific Databases
- Blood Group Antigen Mutation Database
- LRG_814

Identity

HGNC:2901
Gene

DLG2
Long gene name

discs large MAGUK scaffold protein 2
Synonyms gene name
- discs, large homolog 2, chapsyn-110 (Drosophila)
- discs, large homolog 2 (Drosophila)
- discs large homolog 2
Synonyms
- PSD-93
- PSD93
- chapsyn-110
- PPP1R58
Synonyms name
- protein phosphatase 1, regulatory subunit 58
GenBank acession
- U32376
Locus

11q14.1
Discovery year

1997-04-21
Entrez gene record

1740
Pubmed identfication
- 8755482
- 9806853
RefSeq identity
- NM_001364
Classification
- Protein phosphatase 1 regulatory subunits
- Membrane associated guanylate kinases
- PDZ domain containing
VEGA ID

OTTHUMG00000134309