AT-13148

• Catalog number
  B1144-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
• Description
  AT13148 is a potent, ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity. AT13148 blocks AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation inducing concentration dependent apoptosis in cancer cells. It also shows anti-tumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer and PTEN deficient MES-SA uterine tumor in xenografts. Gene expression studies shows that AT13148 has a predominant effect on apoptosis genes.
• CAS Number
  1056901-62-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₆ClN₃O
• Molecular Weight
  313.78
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO(>5 mg/ml))
• Handling
  Protect from air and light
• Tag Line
  AT13148 is a potent multi-AGC kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  24905401
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1C2=CNN=C2)C(CN)(C3=CC=C(C=C3)Cl)O
• InChi
  1S/C17H16ClN3O/c18-16-7-5-15(6-8-16)17(22,11-19)14-3-1-12(2-4-14)13-9-20-21-10-13/h1-10,22H,11,19H2,(H,20,21)/t17-/m0/s1
• InChi Key
  IIRWNGPLJQXWFJ-KRWDZBQOSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AT-13148  
• Gene symbol
  NBN, GNPAT, SLC33A1
• Short name
  AT-13148
• Alternative name
  AT-13148

Gene info

• Identity
  HGNC:7652
• Gene
  NBN
• Long gene name
  nibrin
• Synonyms gene
  • NBS
  • NBS1
• Synonyms gene name
  • Nijmegen breakage syndrome 1 (nibrin)
• Synonyms
  • ATV
  • AT-V2
  • AT-V1
• GenBank acession
  • AF058696
• Locus
  8q21.3
• Discovery year
  1997-11-28
• Entrez gene record
  4683
• Pubmed identfication
  • 9590181
  • 9590180
• RefSeq identity
  • NM_001024688
• Classification
  • MRN complex
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000153546
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_158

Gene info

• Identity
  HGNC:4416
• Gene
  GNPAT
• Long gene name
  glyceronephosphate O-acyltransferase
• Synonyms
  • DHAPAT
  • DAPAT
  • DAP-AT
• Synonyms name
  • glycerone-phosphate O-acyltransferase
  • dihydroxyacetone phosphate acyltransferase
• GenBank acession
  • AF043937
• Locus
  1q42.2
• Discovery year
  1998-10-29
• Entrez gene record
  8443
• Pubmed identfication
  • 9459311
  • 9536089
• VEGA ID
  OTTHUMG00000038024

Gene info

• Identity
  HGNC:95
• Gene
  SLC33A1
• Long gene name
  solute carrier family 33 member 1
• Synonyms gene
  • ACATN
  • SPG42
• Synonyms gene name
  • acetyl-Coenzyme A transporter
  • spastic paraplegia 42 (autosomal dominant)
  • solute carrier family 33 (acetyl-CoA transporter), member 1
• Synonyms
  • AT-1
  • AT1
• GenBank acession
  • D88152
• Locus
  3q25.31
• Discovery year
  1999-02-12
• Entrez gene record
  9197
• Pubmed identfication
  • 9096318
  • 19061983
• RefSeq identity
  • NM_004733
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000158481

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