CHS-828

• Catalog number
  2044-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  GMX1778; (E)-1-[6-(4-Chlorophenoxy)hexyl]-2-cyano-3-(pyridin-4-yl)guanidine
• Description
  A pyridyl cyanoguanidine derivative that displays potent antitumor activity. Also acts as an inhibitor of Nampt/visfatin, NF-kB and IkB kinase. In addition, CHS-828 induces programmed cell death and activates p53.
• CAS Number
  200484-11-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₂ClN₅O
• Molecular Weight
  371.86
• Cell Permeable
  No
• Purity
  ≥98% by NMR
• Solubilities
  DMSO or EtOH
• Handling
  Protect from air and light
• Tag Line
  A Nampt/visfatin, NF-kB and IkB kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  148198
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl
• InChi
  InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15- 21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
• InChi Key
  BOIPLTNGIAPDBY-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CHS-828  
• Gene symbol
  LYST
• Short name
  CHS-828
• Alternative name
  CHS-828

Gene info

• Identity
  HGNC:1968
• Gene
  LYST
• Long gene name
  lysosomal trafficking regulator
• Synonyms gene
  • CHS1
• Synonyms gene name
  • Chediak-Higashi syndrome 1
• Synonyms
  • CHS
  • Mauve
• GenBank acession
  • U70064
• Locus
  1q42.3
• Discovery year
  1996-10-31
• Entrez gene record
  1130
• Pubmed identfication
  • 8717042
  • 8896560
• Classification
  • BEACH domain containing
  • MicroRNA protein coding host genes
  • WD repeat domain containing
• VEGA ID
  OTTHUMG00000040527
• Locus Specific Databases
  • Albinism Database
  • LYSTbase: Mutation registry for Chediak-Higashi syndrome (previously known as CHS1base)
  • Mutations of the Chediak Higashi Syndrome
  • LRG_143

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