LOXO-101
-
Catalog numberB2291-5
-
PricePlease ask
-
Size5 mg
-
-
Alternative_name3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide; ARRY 470; Larotrectinib
-
DescriptionLOXO-101 is a potent, ATP-competitive TRK inhibitor with IC₅₀s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100-fold selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
-
CAS Number1223403-58-4
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₁H₂₂F₂N₆O₂
-
Molecular Weight428.44
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (~5 mg/ml)
-
HandlingProtect from air and light
-
Tag LineA potent, ATP-competitive TRK inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
PubChem CID46188928
-
SMILESC1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F
-
InChiInChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
-
InChi KeyNYNZQNWKBKUAII-KBXCAEBGSA-N
-
MSDS AvailableYES
-
Gene target
-
Gene symbolMIR101-2, MIR101-1, DERL2
-
Short nameLOXO-101
-
Alternative nameLOXO-101
-
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 101-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR101 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 101-1
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR101 family
Gene info
-
Identity
-
Gene
-
Long gene namederlin 2
-
Synonyms gene name
- Der1-like domain family, member 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2004-11-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Rhomboid family
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
-
Tree numbers
- E05.393.220
-
Qualifiersdrug effects, methods, radiation effects