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anti-EHMT2 Antibody

anti-EHMT2 Antibody is available 1 time from Biovision labs

6152-100 | anti-EHMT2 Antibody size: EHMT2 Antibody | 492.66 USD

Catalog number 6152-100
Supplier Biovision
Price 492.66 USD
Size EHMT2 Antibody
1. Gene info
Identity 39751
Gene EHMT2-AS1
Long gene name EHMT2 and SLC44A4 antisense RNA 1
Synonyms gene name
  • EHMT2 antisense RNA 1 (non-protein coding)
  • EHMT2 antisense RNA 1
Locus 6p21.33
Discovery year 2011-04-21
Entrez gene record 106478954
Classification
  • Antisense RNAs
Havana BLAST/BLAT OTTHUMG00000057535
Product images
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Target of this antibody: EHMT2
Alternative names of antibody target: BAT8, C6orf30, DKFZp686H08213, FLJ35547, G9A, KMT1C, NG36, NG3
Background information: G9a, also known as Euchromatic histone­lysine N­methyltransferase 2 (EHMT2), is a member of a family of histone lysine methyltransferases. Recombinant G9a can mono­, di­ and tri­methylate histone H3 on Lys9 and Lys27 in vitro. However, in vivo G9a forms a complex with GLP, a G9a­related histone methyltransferase, and together these proteins function as the major euchromatic histone H3 Lys9 mono­ and di­methyltransferases, creating transcriptionally repressive marks that facilitate gene silencing. G9a methylates itself on Lys165, a modification that regulates the association of HP1 repressor proteins with the G9a/GLP complex. The G9a/GLP complex also contains Wiz, a zinc finger protein that is required for G9a/GLP hetero­dimerization and complex stability. Wiz contains two CtBP co­repressor binding sites, which mediate the association of the G9a/GLP with the CtBP co­repressor complex. In addition, G9a and GLP are components of other large transcriptional co­repressor complexes, such as those involving E2F6 and CDP/cut. G9a interacts with DNMT1, and both proteins are required for methylation of DNA and histone H3 (Lys9) at replication foci, providing a functional link between histone H3 Lys9 and CpG methylation during DNA replication. G9a activity is critical for meiotic prophase progression, as mutant mice deficient in germ line G9a show a large loss of mature gametes. In addition, G9a facilitates increased global levels of di­methyl histone H3 (Lys9) during hypoxic stress and increased G9a expression is associated with hepatocellular carcinoma.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
This antibody reacts with: Human, mouse, rat
Immunogene sequence: Recombinant protein of human EHMT2
Concentration of antibody: 1 mg/ml
Form of antibody: Liquid
Formulation of this antibody: 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: Western blot, Immunohistochemistry
Recommended usage: Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetEHMT2
Short name anti-EHMT2 Antibody
Technique Antibody, anti
Alternative name antibody to-EHMT2 (Antibody to)
Alternative technique antibodies
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anti-EHMT2 Antibody | Technique alternative | 01012193826
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