Abexinostat

Alternative_name

3-(dimethylaminomethyl)-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide; CRA-024781; PCI-24781
Description

Abexinostat is a broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. It inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Abexinostat has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs).
CAS Number

783355-60-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₁H₂₃N₃O₅
Molecular Weight

397.42
Cell Permeable

Yes
Purity

≥96% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A broad-spectrum histone deacetylase (HDAC) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD10565969
PubChem CID

11749858
PubChem CID Link
SMILES

CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO
InChi

InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)
InChi Key

MAUCONCHVWBMHK-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes