STING Antagonist, C-178

• Catalog number
  B2396-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  C-178, STING Antagonist, N-3-Dibenzofuranyl-5-nitrofuran-2-carboxamide
• Description
  STING Antagonist C-178 is a potent inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91.
• CAS Number
  329198-87-0
• Structure Available
  Yes
• Molecular Formula
  C₁₇H₁₀N₂O₅
• Molecular Weight
  322.28
• Cell Permeable
  True
• Purity
  ≥98% by HPLC
• Solubilities
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A STING antagonist
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  2866412
• PubChem CID Link
• SMILES
  C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)NC(=O)C4=CC=C(O4)[N+](=O)[O-]
• InChi
  InChI=1S/C17H10N2O5/c20-17(14-7-8-16(24-14)19(21)22)18-10-5-6-12-11-3-1-2-4-13(11)23-15(12)9-10/h1-9H,(H,18,20)
• InChi Key
  URUVDCCYSJEGQQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True
• Additional description
  The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.

• Gene target
  STING   Antagonist   C-178  
• Gene symbol
  SMC4, MYB, PCK1, SFTPC, VCX3B, MAF, RFX1, EGR4, STING1
• Short name
  STING Antagonist, C-178
• Alternative name
  STING Antagonist, C-178

Gene info

• Identity
  HGNC:14013
• Gene
  SMC4
• Long gene name
  structural maintenance of chromosomes 4
• Synonyms gene
  • SMC4L1
• Synonyms gene name
  • SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
  • SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
• Synonyms
  • hCAP-C
  • CAP-C
• GenBank acession
  • AF092564
• Locus
  3q25.33
• Discovery year
  2001-02-22
• Entrez gene record
  10051
• Pubmed identfication
  • 9789013
  • 10319587
• Classification
  • Structural maintenance of chromosomes proteins
  • Condensin I subunits
  • Condensin II subunits
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000159006

Gene info

• Identity
  HGNC:7545
• Gene
  MYB
• Long gene name
  MYB proto-oncogene, transcription factor
• Synonyms gene name
  • v-myb avian myeloblastosis viral oncogene homolog
• Synonyms
  • c-myb
• Locus
  6q23.3
• Discovery year
  2001-06-22
• Entrez gene record
  4602
• Pubmed identfication
  • 17599807
• Classification
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000015629
• Locus Specific Databases
  • The Globin Gene Server

Gene info

• Identity
  HGNC:8724
• Gene
  PCK1
• Long gene name
  phosphoenolpyruvate carboxykinase 1
• Synonyms gene name
  • phosphoenolpyruvate carboxykinase 1 (soluble)
• Synonyms
  • PEPCK-C
• Locus
  20q13.31
• Discovery year
  1990-09-10
• Entrez gene record
  5105
• Pubmed identfication
  • 1492743
• VEGA ID
  OTTHUMG00000032825

Gene info

• Identity
  HGNC:10802
• Gene
  SFTPC
• Long gene name
  surfactant protein C
• Synonyms gene
  • SFTP2
• Synonyms gene name
  • surfactant, pulmonary-associated protein C
• Synonyms
  • SP-C
  • PSP-C
  • SMDP2
  • BRICD6
• Synonyms name
  • BRICHOS domain containing 6
• Locus
  8p21.3
• Discovery year
  1988-05-11
• Entrez gene record
  6440
• Pubmed identfication
  • 1859376
  • 16709565
• RefSeq identity
  • NM_003018
• Classification
  • BRICHOS domain containing
• VEGA ID
  OTTHUMG00000163775

Gene info

• Identity
  HGNC:31838
• Gene
  VCX3B
• Long gene name
  variable charge X-linked 3B
• Synonyms
  • VCX-C
• Locus
  Xp22.31
• Discovery year
  2005-01-11
• Classification
  • Variable charge X/Y family
• VEGA ID
  OTTHUMG00000021106

Gene info

• Identity
  HGNC:6776
• Gene
  MAF
• Long gene name
  MAF bZIP transcription factor
• Synonyms gene name
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
• Synonyms
  • c-MAF
• Locus
  16q23.2
• Discovery year
  1991-08-01
• Entrez gene record
  4094
• Pubmed identfication
  • 14998484
• Classification
  • Basic leucine zipper proteins
• VEGA ID
  OTTHUMG00000137621

Gene info

• Identity
  HGNC:9982
• Gene
  RFX1
• Long gene name
  regulatory factor X1
• Synonyms gene name
  • regulatory factor X, 1 (influences HLA class II expression)
• Synonyms
  • EF-C
• Synonyms name
  • trans-acting regulatory factor 1
  • enhancer factor C
  • MHC class II regulatory factor RFX
• Locus
  19p13.12
• Discovery year
  1991-11-06
• Entrez gene record
  5989
• Pubmed identfication
  • 1505960
  • 8289803
• RefSeq identity
  • NM_002918
• Classification
  • Regulatory factor X family
• VEGA ID
  OTTHUMG00000181979

Gene info

• Identity
  HGNC:3241
• Gene
  EGR4
• Long gene name
  early growth response 4
• Synonyms
  • NGFI-C
  • PAT133
• Locus
  2p13.2
• Discovery year
  1992-07-27
• Entrez gene record
  1961
• Pubmed identfication
  • 1584812
• RefSeq identity
  • NM_001965
• Classification
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000129774

Gene info

• Identity
  HGNC:27962
• Gene
  STING1
• Long gene name
  stimulator of interferon response cGAMP interactor 1
• Synonyms gene
  • TMEM173
• Synonyms gene name
  • transmembrane protein 173
• Synonyms
  • FLJ38577
  • NET23
  • ERIS
  • MPYS
  • STING
  • MITA
• Synonyms name
  • stimulator of interferon genes
  • endoplasmic reticulum IFN stimulator
• Locus
  5q31.2
• Discovery year
  2006-08-24
• Entrez gene record
  340061
• Pubmed identfication
  • 21947006
• RefSeq identity
  • NM_198282
• VEGA ID
  OTTHUMG00000129239
• Locus Specific Databases
  • LRG_1308

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