STING Antagonist, H-151

Alternative_name

H151, H-151, N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Description

H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
CAS Number

941987-60-6
Structure Available

Yes
Molecular Formula

C₁₇H₁₇N₃O
Molecular Weight

279.34
Cell Permeable

True
Purity

≥98% by HPLC
Solubilities

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A STING antagonist
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

7616033
PubChem CID Link
SMILES

CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
InChi

InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChi Key

UJZDIKVQFMCLBE-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

False
Additional description

The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.

Gene target

STING Antagonist H-151
Gene symbol

NCAPH, HLA-H, PALLD, IGHV3-69-1, MIR151A, FUT1, PIGH, NEFH, ATCAY, RAB11B
Short name

STING Antagonist, H-151
Alternative name

STING Antagonist, H-151

Identity

HGNC:1112
Gene

NCAPH
Long gene name

non-SMC condensin I complex subunit H
Synonyms gene
- BRRN1
Synonyms gene name
- barren (Drosophila) homolog
- barren homolog (Drosophila)
- barren homolog 1 (Drosophila)
- non-SMC condensin I complex, subunit H
Synonyms
- CAP-H
- hCAP-H
GenBank acession
- BC024211
Locus

2q11.2
Discovery year

1998-02-11
Entrez gene record

23397
Pubmed identfication
- 9417923
RefSeq identity
- NM_015341
Classification
- Condensin I subunits
- Kleisins
VEGA ID

OTTHUMG00000130451

Identity

HGNC:5631
Gene

IGHV3-69-1
Long gene name

immunoglobulin heavy variable 3-69-1 (pseudogene)
Synonyms gene
- IGHV3-H
Synonyms gene name
- immunoglobulin heavy variable 3-H (provisional)
- immunoglobulin heavy variable 3-H pseudogene (provisional)
- immunoglobulin heavy variable 3-H (pseudogene)
Synonyms
- IGHV3-h
GenBank acession
- AJ879484
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28402
Pubmed identfication
- 16133446
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000191145

Identity

HGNC:4012
Gene

FUT1
Long gene name

fucosyltransferase 1 (H blood group)
Synonyms gene
- H
- HSC
Synonyms gene name
- fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included)
- fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
Synonyms name
- galactoside 2-alpha-L-fucosyltransferase
Locus

19q13.33
Discovery year

1989-06-06
Entrez gene record

2523
RefSeq identity
- NM_000148
Classification
- Fucosyltransferases
- Blood group antigens
VEGA ID

OTTHUMG00000183325
Locus Specific Databases
- Blood Group Antigen Mutation Database
- LRG_810

Identity

HGNC:7737
Gene

NEFH
Long gene name

neurofilament heavy chain
Synonyms gene name
- neurofilament, heavy polypeptide 200kDa
- neurofilament heavy polypeptide
- neurofilament heavy
Synonyms
- NF-H
- NFH
Locus

22q12.2
Discovery year

1988-08-31
Entrez gene record

4744
RefSeq identity
- NM_021076
Classification
- Intermediate filaments Type IV
VEGA ID

OTTHUMG00000151155
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database