PGP-4008, P-GP Inhibitor

• Catalog number
  BC-090
• Price
  Please ask
• Size
  2 mg

• Description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  PGP-4008   P-GP   Inhibitor  
• Gene symbol
  PGP, PGPEP1, ABCB1, ADAM7, RNF130, GTPBP1, HMGA1P8, PREX1, RASSF9, DLG5
• Short name
  PGP-4008, P-GP Inhibitor
• Alternative name
  PGP-4008, P-GP suppressor

Gene info

• Identity
  HGNC:8909
• Gene
  PGP
• Long gene name
  phosphoglycolate phosphatase
• GenBank acession
  • BC035985
• Locus
  16p13.3
• Discovery year
  2001-06-22
• Entrez gene record
  283871
• RefSeq identity
  • NM_024118
• VEGA ID
  OTTHUMG00000177047

Gene info

• Identity
  HGNC:13568
• Gene
  PGPEP1
• Long gene name
  pyroglutamyl-peptidase I
• Synonyms
  • PGP-I
  • Pcp
  • PGP
  • PGPI
• Synonyms name
  • pyroglutamyl aminopeptidase
• GenBank acession
  • AJ278828
• Locus
  19p13.11
• Discovery year
  2001-01-26
• Entrez gene record
  54858
• RefSeq identity
  • NM_017712
• VEGA ID
  OTTHUMG00000183358

Gene info

• Identity
  HGNC:40
• Gene
  ABCB1
• Long gene name
  ATP binding cassette subfamily B member 1
• Synonyms gene
  • PGY1
  • MDR1
  • CLCS
• Synonyms gene name
  • colchicin sensitivity
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
• Synonyms
  • P-gp
  • CD243
  • GP170
  • ABC20
  • p-170
• Synonyms name
  • multidrug resistance protein 1
• GenBank acession
  • M14758
• Locus
  7q21.12
• Discovery year
  1986-01-01
• Entrez gene record
  5243
• Pubmed identfication
  • 3027054
• RefSeq identity
  • NM_000927
• Classification
  • ATP binding cassette subfamily B
  • CD molecules
• VEGA ID
  OTTHUMG00000023393

Gene info

• Identity
  HGNC:214
• Gene
  ADAM7
• Long gene name
  ADAM metallopeptidase domain 7
• Synonyms gene name
  • a disintegrin and metalloproteinase domain 7
• Synonyms
  • GP-83
  • EAPI
• GenBank acession
  • AF090327
• Locus
  8p21.2
• Discovery year
  1998-12-01
• Entrez gene record
  8756
• Pubmed identfication
  • 15883027
  • 19855936
• RefSeq identity
  • NM_003817
• Classification
  • ADAM metallopeptidase domain containing
• VEGA ID
  OTTHUMG00000097859

Gene info

• Identity
  HGNC:18280
• Gene
  RNF130
• Long gene name
  ring finger protein 130
• Synonyms
  • GP
  • G1RZFP
  • GOLIATH
• GenBank acession
  • AF155650
• Locus
  5q35.3
• Discovery year
  2003-05-21
• Entrez gene record
  55819
• Pubmed identfication
  • 10806348
• RefSeq identity
  • NM_018434
• Classification
  • MicroRNA protein coding host genes
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000130909

Gene info

• Identity
  HGNC:4669
• Gene
  GTPBP1
• Long gene name
  GTP binding protein 1
• Synonyms
  • GP-1
  • HSPC018
• GenBank acession
  • U87964
• Locus
  22q13.1
• Discovery year
  1999-04-22
• Entrez gene record
  9567
• Pubmed identfication
  • 9070279
• RefSeq identity
  • NM_004286
• VEGA ID
  OTTHUMG00000151002

Gene info

• Identity
  HGNC:39183
• Gene
  HMGA1P8
• Long gene name
  high mobility group AT-hook 1 pseudogene 8
• Synonyms
  • HMGA1-p
• Locus
  2p13.1
• Discovery year
  2010-11-17
• Entrez gene record
  100130009
• Pubmed identfication
  • 12727900
  • 20975707
• RefSeq identity
  • NG_032791
• VEGA ID
  OTTHUMG00000152827

Gene info

• Identity
  HGNC:32594
• Gene
  PREX1
• Long gene name
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
• Synonyms gene name
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
• Synonyms
  • KIAA1415
  • P-REX1
• Synonyms name
  • PIP3 dependent Rac exchange factor 1
• GenBank acession
  • AB037836
• Locus
  20q13.13
• Discovery year
  2008-09-15
• Entrez gene record
  57580
• Pubmed identfication
  • 11955434
  • 15545267
  • 16301320
• RefSeq identity
  • NM_020820
• Classification
  • PDZ domain containing
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000032685

Gene info

• Identity
  HGNC:15739
• Gene
  RASSF9
• Long gene name
  Ras association domain family member 9
• Synonyms gene
  • PAMCI
• Synonyms gene name
  • peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
  • Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
• Synonyms
  • P-CIP1
• Locus
  12q21.31
• Discovery year
  2001-05-23
• Entrez gene record
  9182
• Pubmed identfication
  • 9837933
  • 18272789
• Classification
  • Ras association domain family
• VEGA ID
  OTTHUMG00000169831

Gene info

• Identity
  HGNC:2904
• Gene
  DLG5
• Long gene name
  discs large MAGUK scaffold protein 5
• Synonyms gene name
  • discs, large homolog 5 (Drosophila)
  • discs large homolog 5
• Synonyms
  • P-dlg
  • KIAA0583
• GenBank acession
  • U61843
• Locus
  10q22.3
• Discovery year
  1999-02-23
• Entrez gene record
  9231
• Pubmed identfication
  • 9738934
• RefSeq identity
  • NM_004747
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000018548

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