NSC-87877
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Catalog number2687-10
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PricePlease ask
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Size10 mg
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Alternative_name8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
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DescriptionNSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
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CAS Number56990-57-9
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₁₉H₁₃N₃O₇S₂
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Molecular Weight459.45
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesH₂O (~20 mg/ml) or DMSO (~ 5 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA potent SHP-1/SHP-2 protein tyrosine phosphatases inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life36 months
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MDL NumberMFCD09971104
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PubChem CID5459322
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SMILESC1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)C=C2S(=O)(=O)O)N=C1
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InChiInChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,21H,(H,24,25,26)(H,27,28,29)/b22-16+
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InChi KeyBIQBDHSYQMHHPU-CJLVFECKSA-N
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MSDS AvailableYes
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Gene target
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Short nameNSC-87877
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Alternative nameNSC-87877
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