NSC-87877

• Catalog number
  2687-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
• Description
  NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 and 318 nM, respectively). It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
• CAS Number
  56990-57-9
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₉H₁₃N₃O₇S₂
• Molecular Weight
  459.45
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  H₂O (~20 mg/ml) or DMSO (~ 5 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent SHP-1/SHP-2 protein tyrosine phosphatases inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD09971104
• PubChem CID
  5459322
• PubChem CID Link
• SMILES
  C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)C=C2S(=O)(=O)O)N=C1
• InChi
  InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,21H,(H,24,25,26)(H,27,28,29)/b22-16+
• InChi Key
  BIQBDHSYQMHHPU-CJLVFECKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NSC-87877  
• Short name
  NSC-87877
• Alternative name
  NSC-87877

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