Bromodomain Inhibitor, (+)-JQ1
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Catalog number2070-5
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Price:
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Size5 mg
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Alternative_namet-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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DescriptionCell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
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CAS Number1268524-70-4
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Structure AvailableYes
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Molecular FormulaC₂₃H₂₅ClN₄O₂S
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Molecular Weight456.99
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (10 mM)
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HandlingProtect from air and moisture
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Tag LineA potent and highly specific BET inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD19443648
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PubChem CID46907787
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SMILESCC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
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InChiInChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15) 25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2, 1-6H3/t17-/m0/s1
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InChi KeyDNVXATUJJDPFDM-KRWDZBQOSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short nameBromodomain Inhibitor, (+)-JQ1
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Alternative nameBromodomain suppressor, (+)-JQ1
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