Target of this antibody:
Alternative names of antibody target:
Cbp/p300-interacting transactivator 2, melanocyte-specific gene 1-related gene 1, MSG-related protein 1, MRG1, melanocyte specific gene 2, MSG2, ER154-like, ASD8, VSD2
CITED2 was initially identified as a potential transcriptional activator with significant homology to MSG1, a melanocyte-specific nuclear protein. CITED2 interacts with the histone acetyltransferase p300/CBP and acts as a coactivator to several DNA-binding transcription factors such as HIF-1 and AP-2. CITED2 also controls proliferation of mouse embryonic fibroblasts via the polycomb group genes Bmi-1 and Mel18 and the tumor suppressor Ink4a/Arf. CITED2 has also been found to be an essential regulator of adult hematopoietic stem cells (HSCs), with conditional deletion of CITED2 in the adult mouse resulting in the loss of HSCs, multilineage bone marrow failure and increased lethality.
Clonality of antibody:
This antibody reacts with:
Human, mouse, rat
CITED2 antibody was raised against an 18 amino acid peptide near the amino terminus of human CITED2.
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
Affinity chromatography purified via peptide column
This antibody has been succesfully tested for use in following methods:
Western blot, ELISA
Western Blot: 1 - 2 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
anti-CITED2 Antibody (NT)
antibody to-Cbp/p300-interacting transactivator, including L-gutamic acid/L-aspartic acid-rich carboxy-terminal domain, 2 (Antibody to) (NT)
Alternative to gene target
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, ASD8 and MRG-1 and MRG1 and P35SRJ and VSD2, CITED2 and IDBG-97161 and ENSG00000164442 and 10370, LBD domain binding, nuclei, Cited2 and IDBG-134872 and ENSMUSG00000039910 and 17684, CITED2 and IDBG-633814 and ENSBTAG00000011224 and 521378