p53

• Catalog number
  GEN438483
• Price
  Please ask
• Size
  100ug

• Also known as
  p53
• Other names
  cellular tumor antigen p53 isoform a; Cellular tumor antigen p53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  TP53
• Gene name synonims
  N/A
• Other gene names
  TP53; TP53; P53; BCC7; LFS1; TRP53; P53
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG2b / kappa
• Clone
  DO-7
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens), Monkey, Cow.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

• Gene target
  p53  
• Gene symbol
  MDM4, TP53, LNCPRESS2
• Short name
  p53
• Alternative name
  Anti-p53

Gene info

• Identity
  HGNC:6974
• Gene
  MDM4
• Long gene name
  MDM4 regulator of p53
• Synonyms gene name
  • mouse double minute 4, human homolog of; p53-binding protein
  • Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
  • Mdm4 p53 binding protein homolog (mouse)
  • MDM4, p53 regulator
• Synonyms
  • MDMX
  • HDMX
• GenBank acession
  • AF007111
• Locus
  1q32.1
• Discovery year
  1997-09-05
• Entrez gene record
  4194
• Pubmed identfication
  • 9226370
  • 14660608
  • 26798135
• RefSeq identity
  • NM_002393
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000035877

Gene info

• Identity
  HGNC:11998
• Gene
  TP53
• Long gene name
  tumor protein p53
• Synonyms
  • p53
  • LFS1
• Synonyms name
  • Li-Fraumeni syndrome
• GenBank acession
  • AF307851
• Locus
  17p13.1
• Discovery year
  1986-01-01
• Entrez gene record
  7157
• Pubmed identfication
  • 6396087
  • 3456488
  • 2047879
• RefSeq identity
  • NM_000546
• VEGA ID
  OTTHUMG00000162125
• Locus Specific Databases
  • IARC TP53 Mutation Database
  • p53 UMD TP53 mutation database
  • Database of Germline p53 Mutations
  • MUTP53LOAD, Mutant p53 Loss Of Activity Database
  • LRG_321

Gene info

• Identity
  HGNC:52747
• Gene
  LNCPRESS2
• Long gene name
  lncRNA p53 regulated and ESC associated 2
• Synonyms name
  • lncRNA p53 regulated and ESC specific 2
• Locus
  4q22.1
• Discovery year
  2016-12-14
• Entrez gene record
  101929194
• Pubmed identfication
  • 27912097
• RefSeq identity
  • NR_125920
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000160917

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