MDC1 Antibody, ALEXA FLUOR 594
-
Catalog number
bs-2400R-A594
-
Price
Please ask
-
Size
100ul
-
-
Long name
MDC1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
-
Also known as
Anti-MDC1 PAb ALEXA FLUOR 594
-
Category
Conjugated Primary Antibodies
-
Conjugated with
ALEXA FLUOR® 594
-
Host Organism
Rabbit (Oryctolagus cuniculus)
-
Target Antigen
MDC1
-
Specificity
This is a highly specific antibody against MDC1.
-
Modification
Unmodified
-
Modification Site
None
-
Clonality
Polyclonal
-
Clone
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Immunogen range
45-90/2089
-
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MDC1
-
Gene ID Number
9656
-
Swiss Prot
Q14676
-
Tested applications
IF(IHC-P)
-
Recommended dilutions
IF(IHC-P)(1:50-200)
-
Crossreactivity
Human, Mouse, Rat
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigen
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
-
Purification
Purified by Protein A.
-
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission
590nm/617nm
-
Synonyms
NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1; MDC1; KIAA0170
-
Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Conjugation
Alexa Fluor, ALEXA FLUOR® 594
-
Conjugated
Alexa conjugate 1
-
French translation
anticorps
-
Gene target
-
Gene symbol
MDC1-AS1, MDC1
-
Short name
Anti-MDC1
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
Immunoglobulin G (IgG)
-
Label
ALEXA FLUOR 594
-
Alternative name
MDC1 Polyclonal Antibody, ALEXA FLUOR 594
-
Alternative technique
antibodies
-
Alternative to gene target
mediator of DNA-damage checkpoint 1, NFBD1, MDC1 and IDBG-76700 and ENSG00000137337 and 9656, FHA domain binding, nuclei, Mdc1 and IDBG-179187 and ENSMUSG00000061607 and 240087, MDC1 and IDBG-634528 and ENSBTAG00000025526 and 511168
-
Gene info
-
Identity
-
Gene
-
Long gene name
MDC1 antisense RNA 1
-
Synonyms gene name
- MDC1 antisense RNA 1 (non-protein coding)
-
Synonyms
-
Locus
-
Discovery year
2011-04-21
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
-
VEGA ID
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
