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Alternative_name
(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
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Description
Bioymifi is a potent and selective death receptor 5 (DR5) activator. Bioymifi works by mimicking the ability of TRAIL, the natural DR5 ligand, to stimulate clustering of DR5, triggering apoptosis. Bioymifi caused apoptosis and cell death in a variety of human cancer cell lines including T98G human glioblastoma cells, lung cancer cell lines H460 and H1155, the cervical cancer cell line HeLa, the osteosarcoma cell line U2OS, the pancreatic carcinoma cell line Miapaca and the colon cancer cell line HT29.
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CAS Number
1420071-30-2
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₂H₁₂BrN₃O₄S
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Molecular Weight
494.32
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~ 2 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent and selective death receptor 5 (DR5) activator
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
70678419
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SMILES
C1=CC(=CC=C1N2C(=O)C(=CC3=CC=C(O3)C4=CC5=C(C=C4)C(=O)NC5=O)SC2=N)Br
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InChi
InChI=1S/C22H12BrN3O4S/c23-12-2-4-13(5-3-12)26-21(29)18(31-22(26)24)10-14-6-8-17(30-14)11-1-7-15-16(9-11)20(28)25-19(15)27/h1-10,24H,(H,25,27,28)/b18-10-,24-22?
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InChi Key
ULBOWKXOFOTCMU-NLDKGBHCSA-N
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MSDS Available
Yes