U-18666A

• Catalog number
  9469-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
• Description
  U-18666A is a cell-permeable cholesterol trafficking inhibitor. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.
• CAS Number
  3039-71-2
• Structure Available
  Yes
• Molecular Formula
  C₂₅H₄₁F₂NO₂.HCl
• Molecular Weight
  424.07
• Cell Permeable
  Yes
• Purity
  ≥95%
• Solubilities
  H₂O (>30 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A cell-permeable cholesterol trafficking inhibitor.
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00210908
• PubChem CID
  9954082
• PubChem CID Link
• SMILES
  CCN(CC)CCOC1CCC2(C3CCC4(C(C3CC=C2C1)CCC4=O)C)C.Cl
• InChi
  nChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
• InChi Key
  GZFYZYBWLCYBMI-MYZJJQSMSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  U-18666A  
• Gene symbol
  HLA-U, UTS2, CENPU
• Short name
  U-18666A
• Alternative name
  U-18666A

Gene info

• Identity
  HGNC:23477
• Gene
  HLA-U
• Long gene name
  major histocompatibility complex, class I, U (pseudogene)
• Synonyms gene
  • HLA-21
• Synonyms gene name
  • HLA-21 pseudogene
• Synonyms
  • Em:AB023056.13
• GenBank acession
  • M96330
• Locus
  6p22.1
• Discovery year
  2004-01-16
• Entrez gene record
  352965
• RefSeq identity
  • NG_002398
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031245
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:12636
• Gene
  UTS2
• Long gene name
  urotensin 2
• Synonyms
  • UII
  • U-II
  • UCN2
  • PRO1068
• Synonyms name
  • prepro U-II
• GenBank acession
  • AF104118
• Locus
  1p36.23
• Discovery year
  2000-03-22
• Entrez gene record
  10911
• Pubmed identfication
  • 9861051
  • 10499587
• RefSeq identity
  • NM_006786
• Classification
  • Receptor ligands
  • Neuropeptides
• VEGA ID
  OTTHUMG00000001218

Gene info

• Identity
  HGNC:21348
• Gene
  CENPU
• Long gene name
  centromere protein U
• Synonyms gene
  • MLF1IP
• Synonyms gene name
  • MLF1 interacting protein
• Synonyms
  • CENP-U
  • KLIP1
  • CENP-50
  • PBIP1
• Synonyms name
  • polo-box-interacting protein 1
• GenBank acession
  • AK027121
  • AF516710
• Locus
  4q35.1
• Discovery year
  2003-07-17
• Entrez gene record
  79682
• Pubmed identfication
  • 15116101
  • 16622420
  • 16622419
• RefSeq identity
  • NM_024629
• Classification
  • Constitutive centromere associated network
• VEGA ID
  OTTHUMG00000160499

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