MTX-211

Alternative_name

N-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]pyridin-3-yl]methanesulfonamide
Description

MTX-211 is a dual inhibitor of EGFR and PI3K. Potentially useful for treatment of KRAS mutant colorectal cancer.
CAS Number

1952236-05-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₄Cl₂FN₅O₂S
Molecular Weight

478.33
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A dual inhibitor of EGFR and PI3K
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

121416213
PubChem CID Link
SMILES

CS(=O)(=O)NC1=C(N=CC(=C1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)Cl
InChi

InChI=1S/C20H14Cl2FN5O2S/c1-31(29,30)28-18-7-12(9-24-19(18)22)11-2-5-17-14(6-11)20(26-10-25-17)27-13-3-4-16(23)15(21)8-13/h2-10,28H,1H3,(H,25,26,27)
InChi Key

GUYKCXXNIKKSBC-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes