EUK-118

Alternative_name

(acetato-κO)[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
Description

A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC₅₀ value of 2.0 µm.
CAS Number

186299-34-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₅MnN₂O₈
Molecular Weight

500.38
Cell Permeable

Yes
Purity

≥95%
Solubilities

DMSO (~ 20 mg/ml)
Handling

Protect from air and moisture
Tag Line

A SOD and catalase mimetic
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
SMILES

CC(=O)[O-][Mn]123([N+](=Cc4c(cc(cc4OC)OC)[O-]1)CC[N+]2=Cc5c(cc(cc5OC)OC)[O-]3)[Mn][Mn+]
InChi

InChI=1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;1-2(3)4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4);;;/q;;;+1;+2/p-3/b21-11+,22-12+;;;;
InChi Key

NKZPUKNJLPQHHM-CAGONKBASA-K
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:5765
Gene

IGKV1OR15-118
Long gene name

immunoglobulin kappa variable 1/OR15-118 (pseudogene)
Synonyms gene
- IGKVP2
Synonyms gene name
- immunoglobulin kappa variable 1/OR15-118
- immunoglobulin kappa variable 1/OR15-118 pseudogene
Synonyms
- IGKV1/OR-118
- IGKV1/OR15-118
Locus

15 not on reference assembly
Discovery year

2000-04-18
Entrez gene record

100312985
Classification
- Immunoglobulin kappa (IGK) orphons

Identity

HGNC:16653
Gene

MRPL48
Long gene name

mitochondrial ribosomal protein L48
Synonyms
- CGI-118
GenBank acession
- AF151876
Locus

11q13.4
Discovery year

2001-10-12
Entrez gene record

51642
Pubmed identfication
- 10810093
RefSeq identity
- NM_016055
Classification
- Large subunit mitochondrial ribosomal proteins
- Mitochondrial ribosomal proteins
VEGA ID

OTTHUMG00000168048