anti-CXCR4 Antibody
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Catalog number1009
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoCXCR4 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
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Gene namesCXCR4 Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E
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Antibodie s labelunlabelled serum
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PurityCXCR4 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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Spicific toCXCR4 Antibody is predicted to not cross-react with other CXCR familiy members.
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AntigenCXCR4 antibody was made against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4.
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Immuno applicationELISA, Western Blot, immuno-cyto-chemistry, immuno precipitation, immuno fluorescence, FLOW
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Antibody adviceCXCR4 antibody can be used for Western blot at 1 - 2 ug/mL dilution and for immunoprecipitation and immunocytochemistry at 10 ug/mL. Immunofluorescence starting at 20 ug/mL. Flow Cytometry at 0.1 ug/ml
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Suspention pH azideCXCR4 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atCXCR4 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse
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Omim nr4503175
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Ncbi nrNP_003458
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr7852
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GENE symbolCXCR4
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Antigene namechemokine (C-X-C motif) receptor 4
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SourceHomo sapiens
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Protein nrCXCR4
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCXCR4
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Short nameanti-CXCR4 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toCXCR4 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetchemokine (C-X-C motif) receptor 4, CD184 and D2S201E and FB22 and HM89 and HSY3RR and LAP-3 and LAP3 and LCR1 and LESTR and NPY3R and NPYR and NPYRL and NPYY3R and WHIM, CXCR4 and IDBG-71032 and ENSG00000121966 and 7852, ubiquitin binding, Cell surfaces, Cxcr4 and IDBG-189999 and ENSMUSG00000045382 and 12767, CXCR4 and IDBG-642187 and ENSBTAG00000001060 and 281736
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Gene info
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Identity
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Gene
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Long gene nameC-X-C motif chemokine receptor 4
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Synonyms gene name
- chemokine (C-X-C motif), receptor 4 (fusin)
- chemokine (C-X-C motif) receptor 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-09-17
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Entrez gene record
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Pubmed identfication
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Classification
- C-X-C motif chemokine receptors
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data