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Target antigen
RANK
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human RANK(29-44aa QIAPPCTSEKHYEHLG).
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the RANK Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The RANK Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Receptor Activator of Nuclear Factor K B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL(Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al.(1997) mapped the RANK gene to 18q22.1.
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Related articles
1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999). "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families". Endocr. Rev. 20 (3): 345–57. 2. Wong BR, Josien R, Choi Y (1999). "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function". J. Leukoc. Biol. 65 (6): 715–24. 3. Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795–823.
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Gene Name
TNFRSF11A
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Protein Name
Tumor necrosis factor receptor superfamily member 11A
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Gene Full Name
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
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Synonyms
Activator of NFKB antibody|CD 265 antibody|CD265 antibody|CD265 antigen antibody|EOF antibody|FEO antibody|LOH18CR1 antibody|Loss of heterozygosity 18 chromosomal region 1 antibody|mRANK antibody|NFKB activator antibody|ODFR antibody|OFE antibody|OPTB7 antibody|Osteoclast differentiation factor receptor antibody|OSTS antibody|PDB 2 antibody|PDB2 antibody|RANK antibody|Receptor activator of NF KB antibody|Receptor activator of NF-KB antibody|receptor activator of nuclear factor kappa B antibody|TNFRSF 11A antibody|TNFRSF11A antibody|TNFSF11 antibody|TNR11_HUMAN antibody|TRANCE R antibody|TRANCER antibody|Tumor necrosis factor receptor superfamily member 11a NFKB activator antibody|Tumor necrosis factor receptor superfamily member 11a activator of NFKB antibody|Tumor Necrosis Factor Receptor Superfamily Member 11a antibody
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Uniprot ID
Q9Y6Q6
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
