BTK Inhibitor, PCI-32765
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Catalog number2298-25
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PricePlease ask
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Size25 mg
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Alternative_name2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; Ibrutinib; CRA-032765
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DescriptionA potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC₅₀ = 0.5 nM) with potential antineoplastic activity. It.binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK.
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CAS Number936563-96-1
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Structure AvailableYes
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Peptide sequenceNo
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Salt FormNo
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Molecular FormulaC₂₅H₂₄N₆O₂
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Molecular Weight440.5
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>80 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent Bruton's Tyrosine Kinase (BTK) inhibitor
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD20261150
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PubChem CID16126651
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SMILESC=CC(=O)N1CCCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
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InChiInChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
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InChi KeyXYFPWWZEPKGCCK-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolSERPINA5, BTK
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Short nameBTK Inhibitor, PCI-32765
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Alternative nameBruton agammaglobulinemia tyrosine kinase suppressor, PCI-32765
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Alternative to gene targetBruton agammaglobulinemia tyrosine kinase, AGMX1 and AT and ATK and BPK and IMD1 and PSCTK1 and XLA, BTK and IDBG-79651 and ENSG00000010671 and 695, phosphatidylinositol-3, nuclei, Btk and IDBG-171427 and ENSMUSG00000031264 and 12229, BTK and IDBG-633447 and ENSBTAG00000019250 and 533459
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Gene info
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Identity
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Gene
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Long gene nameserpin family A member 5
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Synonyms gene
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Synonyms gene name
- serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-10-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Serpin peptidase inhibitors
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameBruton tyrosine kinase
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Synonyms gene
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Synonyms gene name
- Bruton agammaglobulinemia tyrosine kinase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tec family tyrosine kinases
- SH2 domain containing
- Pleckstrin homology domain containing
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VEGA ID
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Locus Specific Databases
