anti- MSH6 antibody

• Catalog number
  FNab05375
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
• Immunogen
  mutS homolog 6
• Synonyms
  G/T mismatch binding protein, GTBP, GTMBP, hMSH6, HNPCC5, HSAP, MSH6, MutS alpha 160 kDa subunit, mutS homolog 6 (E. coli), p160
• Calculated MW
  160 kDa
• Uniprot ID
  P52701
• Specificity
  Human, Mouse, Monkey
• Tested Application
  ELISA, WB, IHC, IF
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100
• Image1
  Immunohistochemistry of paraffin-embedded human spleen using FNab05375(MSH6 antibody) at dilution of 1:100
• Image4
  HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab05375(MSH6 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MSH6  
• Gene symbol
  MSH6
• Short name
  anti- MSH6 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- mutS homolog 6 (E. coli) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  mutS homolog 6 (E. coli), GTBP and GTMBP and HNPCC5 and HSAP and p160, MSH6 and IDBG-51044 and ENSG00000116062 and 2956, ADP binding, nuclei, Msh6 and IDBG-201548 and ENSMUSG00000005370 and 17688, BT.98842 and IDBG-633641 and ENSBTAG00000001424 and 540526

Gene info

• Identity
  HGNC:7329
• Gene
  MSH6
• Long gene name
  mutS homolog 6
• Synonyms gene
  • GTBP
• Synonyms gene name
  • mutS (E. coli) homolog 6
  • mutS homolog 6 (E. coli)
• GenBank acession
  • U54777
• Locus
  2p16.3
• Discovery year
  1995-08-29
• Entrez gene record
  2956
• Pubmed identfication
  • 7604266
• RefSeq identity
  • NM_000179
• Classification
  • MutS homologs
  • PWWP domain containing
• VEGA ID
  OTTHUMG00000129129
• Locus Specific Databases
  • Hereditary Non-Polyposis Colorectal Cancer, HNPCC
  • Global Variome shared LOVD
  • MSH6 database at LOVD-China
  • LRG_219

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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