Recombinant Mouse CD62L / L-Selectin / SELL Protein (His & Fc tag) 200µg

• Catalog number
  PKSM040886-200µg
• Price
  Please ask
• Size
  200µg

• Activity
  Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When cells are added to SELL coated plates (10 μg/mL, 100 μL/well) approximately >60% cells will adhere specifically.
• Synonym
  AI528707;CD62L;L-selectin;LECAM-1;Lnhr;Ly-22;Ly-m22;Lyam-1;Lyam1
• Sequence
  Met 1-Asn 332
• Fusion tag
  C-His & Fc
• Accession
  NP_035476.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  61 kDa
• AP Mol Mass
  100-110 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD62L   L-Selectin   SELL   Protein   His   tag   200µg  
• Gene symbol
  SELL
• Short name
  Recombinant Mouse CD62L / L-Selectin / SELL Protein (His & Fc tag) 200µg
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse CD62L / L-Selectin / selectin L Protein (histidine & fragment c detection labelled) 200µg
• Alternative technique
  rec, murine
• Alternative to gene target
  selectin L, CD62L and LAM1 and LECAM1 and LEU8 and LNHR and LSEL and LYAM1 and PLNHR and TQ1, SELL and IDBG-104696 and ENSG00000188404 and 6402, cell adhesion molecule binding, Cell surfaces, Sell and IDBG-202318 and ENSMUSG00000026581 and 20343, SELL and IDBG-631879 and ENSBTAG00000011515 and 281485

Gene info

• Identity
  HGNC:10720
• Gene
  SELL
• Long gene name
  selectin L
• Synonyms gene
  • LYAM1
  • LNHR
• Synonyms gene name
  • lymphocyte adhesion molecule 1
• Synonyms
  • LSEL
  • LAM1
  • LAM-1
  • hLHRc
  • Leu-8
  • Lyam-1
  • PLNHR
  • CD62L
• GenBank acession
  • M25280
• Locus
  1q24.2
• Discovery year
  1989-06-07
• Entrez gene record
  6402
• Pubmed identfication
  • 2664786
  • 1375831
• RefSeq identity
  • NM_000655
• Classification
  • Sushi domain containing
  • Selectins
  • C-type lectin domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000034809

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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