Crenolanib

• Catalog number
  9679-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP-868596; ARO 002
• Description
  Crenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also displays inhibitory activity against PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells.
• CAS Number
  670220-88-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₆H₂₉N₅O₂
• Molecular Weight
  443.54
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>40 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A highly selective and potent FLT3 tyrosine kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  10366136
• PubChem CID Link
• SMILES
  CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
• InChi
  InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
• InChi Key
  DYNHJHQFHQTFTP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Crenolanib  
• Short name
  Crenolanib
• Alternative name
  Crenolanib

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