Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA Protein(C-Fc) 50µg
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Catalog number
PKSH032753-50µg
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Price
Please ask
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Size
50µg
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Synonym
MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1
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Activity
NA
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Sequence
Ala23-Glu308
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Fusion tag
C-Fc
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Accession
Q29983
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Expressed Host
Human cells
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
＞95% as determined by reducing SDS-PAGE.
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Endotoxin
＜1.0 EU per µg as determined by LAL test.
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Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass
59.9 kDa
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AP Mol Mass
88 kDa
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Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Reconstitution
Please refer to it for detailed information.
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Background
MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
MICA-AS1, MICA
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Short name
Recombinant MHC Class I Polypeptide- Sequence A/MICA Protein(C-Fc) 50µg
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Major histocompabitility complex Class I multipeptide-Related Sequence A/Major histocompabitility complex class I polypeptide-related sequence A Protein(C-fragment c) 50µg
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Alternative technique
rec
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Alternative to gene target
MHC class I polypeptide-related sequence A, MICA and IDBG-77578 and ENSG00000204520 and 100507436, protein binding, Plasma membranes
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Gene info
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Identity
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Gene
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Long gene name
MICA antisense RNA 1
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Locus
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Discovery year
2017-08-04
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Entrez gene record
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RefSeq identity
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Classification
Gene info
MeSH Data
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Name
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Concept
Scope note:
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
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Tree numbers
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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