NS-1619

• Catalog number
  B1303-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
• Description
  NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).
• CAS Number
  153587-01-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₈F₆N₂O₂
• Molecular Weight
  362.23
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00928190
• PubChem CID
  4552
• PubChem CID Link
• SMILES
  C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O
• InChi
  InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
• InChi Key
  YLFMCMWKHSDUCT-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  NS-1619  
• Gene symbol
  GNL3, IVNS1ABP, SPINK5
• Short name
  NS-1619
• Alternative name
  NS-1619

Gene info

• Identity
  HGNC:29931
• Gene
  GNL3
• Long gene name
  G protein nucleolar 3
• Synonyms gene name
  • guanine nucleotide binding protein-like 3 (nucleolar)
• Synonyms
  • C77032
  • E2IG3
  • MGC800
  • NS
• Synonyms name
  • nucleostemin
• GenBank acession
  • AK027514
• Locus
  3p21.1
• Discovery year
  2005-01-10
• Entrez gene record
  26354
• Pubmed identfication
  • 11085516
  • 12464630
• RefSeq identity
  • NM_014366
• Classification
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000158752

Gene info

• Identity
  HGNC:16951
• Gene
  IVNS1ABP
• Long gene name
  influenza virus NS1A binding protein
• Synonyms
  • NS1-BP
  • HSPC068
  • NS-1
  • KIAA0850
  • ND1
  • KLHL39
  • ARA3
• Synonyms name
  • kelch-like family member 39
  • Aryl hydrocarbon receptor-associated protein 3
• GenBank acession
  • AB020657
• Locus
  1q25.3
• Discovery year
  2003-05-19
• Entrez gene record
  10625
• Pubmed identfication
  • 9696811
  • 10048485
  • 16582008
• RefSeq identity
  • NM_006469
• Classification
  • BTB domain containing
  • Kelch like
• VEGA ID
  OTTHUMG00000035384

Gene info

• Identity
  HGNC:15464
• Gene
  SPINK5
• Long gene name
  serine peptidase inhibitor Kazal type 5
• Synonyms gene name
  • serine protease inhibitor, Kazal type 5
• Synonyms
  • VAKTI
  • LEKTI
  • LETKI
  • NETS
  • NS
  • FLJ21544
  • FLJ97536
  • FLJ97596
  • FLJ99794
  • DKFZp686K19184
• Synonyms name
  • lymphoepithelial Kazal-type-related inhibitor
• GenBank acession
  • AJ228139
• Locus
  5q32
• Discovery year
  2001-03-30
• Entrez gene record
  11005
• Pubmed identfication
  • 10419450
• RefSeq identity
  • NM_001127698
• Classification
  • Serine peptidase inhibitors, Kazal type
• VEGA ID
  OTTHUMG00000134305
• Locus Specific Databases
  • SPINK5base: Mutation registry for Netherton syndrome
  • LRG_110

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